It is clear from the study of history and news coverage over the past half century that Republican Presidential candidate and even Republican Presidents have NOT been enamored with their Vice Presidential running mates or Vice Presidents.
We go back to Richard Nixon and Spiro Agnew as the first example, with Nixon using Agnew to attack the news media and Democrats in the midterm 1970 Congressional elections, but having little personal regard for him, and unwilling to come to his support when Agnew was revealed to be engaged in corruption, which would force his resignation in October 1973.
Then, Nixon selected Gerald Ford as his Vice Presidential replacement more on the idea that he felt that Ford, while well liked in Congress, would not be seen by opposition Democrats as all that competent to replace Nixon during the impeachment crisis of 1973-1974.
Gerald Ford seems to have really admired and felt comfortable with Nelson Rockefeller as his Vice President under the 25th Amendment, but agreed to drop him from the ticket in 1976 to please conservatives, led by Ronald Reagan, and to select Senator Bob Dole of Kansas as his replacement.
Ronald Reagan may have utilized George H. W. Bush’s expertise, but had little personal regard for Bush, and the Bushes were never invited to dinner at the White House during the eight years of their association.
Bush certainly had little faith and trust in Dan Quayle during his Presidency, and the nation knew it, and worried about the incompetence of Quayle.
Bob Dole’s selection of Jack Kemp in 1996 to be his running mate as Vice President certainly was not as a result of friendship or warmth, and they seemed an ill fit, often disagreeing during the campaign.
George W. Bush selected Dick Cheney in 2000 due to his vast experience, and allowed himself to be dominated in the first term, but their association soured dramatically in the second term.
John McCain seems to have been forced to select Sarah Palin in 2008, and Palin helped to undermine McCain, but McCain continues to defend Palin even today, although it seems clear how uncomfortable he is when answering questions about Palin.
The Mitt Romney-Paul Ryan connection in 2012 seems also not to have been one of great warmth and friendship.
And Mike Pence is squirming a lot as Vice Presidential running mate for Donald Trump, seeing Trump contradict him openly and making clear his lack of regard for Pence, including being upset that Pence performed better in his debate with Tim Kaine, than Trump did with Hillary Clinton in their three Presidential debates.